Adynamic bone disease--bone and beyond

Adynamic bone disease—bone and beyond

Disturbances of bone and mineral metabolism are a hallmark of chronic kidney disease (CKD). Renal osteodystrophy (ROD) is the traditional term for bone lesions in conjunction with CKD and is now considered a part of the ‘chronic kidney disease—mineral and bone disorder’ (CKD-MBD) [1]. ROD comprises various subtypes with substantial differences in aetiology and fundamental differences in treatme...

A Novel Murine Model Of Adynamic Bone Disease (ABD)

Improvement of adynamic bone disease after renal transplantation.

Low bone remodeling and relatively low serum parathyroid hormone (PTH) levels characterize adynamic bone disease (ABD). The impact of renal transplantation (RT) on the course of ABD is unknown. We studied prospectively 13 patients with biopsy-proven ABD after RT. Bone histomorphometry and bone mineral density (BMD) measurements were performed in the 1st and 12th months after RT. Serum PTH, 25-h...

Management of adynamic bone disease in chronic kidney disease: A brief review

The Kidney Disease: Improving Global Outcomes (KDIGO) work group released recommendations in 2006 to define the bone-related pathology associated with chronic kidney disease as renal osteodystrophy. In 2009, KDIGO released revised clinical practice guidelines which redefined systemic disorders of bone and mineral metabolism due to chronic kidney disease as chronic kidney disease-mineral and bon...

Bone and Bone Disease

A SYMPOSIUM on "Bone and Bone Disease" was held in the Medical Biology Centre (Q.U.B.) on Friday, 14th February, 1975, under the joint auspices of the Royal College of Physicians of Edinburgh, the Northern Ireland Council for Postgraduate Medical Education, and the Ulster Medical Society. The Symposium proved extremely popular and was attended by over two hundred doctors. The large attendance w...